结论:褪黑激素可明显抑制烧伤后肺组织氧化应激损伤和肺水肿,对烧伤早期急性肺损伤具有一定的保护作用。
CONCLUSION: MLT may act an effective protection against the acute lung injury by obviously restraining oxidative stress injury and pulmonary oedema in lung tissues of severely-burned rats.
氧化应激可以导致DNA链断裂、DNA位点突变、DNA双链畸变和原癌基因与肿瘤抑制基因突变等形式的DNA损伤;
Oxidative stress can cause DNA damage, such as DNA strand breaks, point mutations, aberrant DNA cross-linking, and mutations in proto-oncogenes and tumor suppressor genes;
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