...B1基因致病突变检测 液相色谱(High-Performance Liquid Chromatography，DHPLC)或高分辨熔解曲线分析(High Resolution Melting，HRM)做为初筛工具，结合测序验证，对31名中国汉族视网膜母细胞瘤患者进行了RB1基因外显子及邻近内含子区域..
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或高分辨熔解曲线分析 High Resolution Melting
高分辨熔解曲线分析法 High Resolution Melting
高分辨率熔解曲线分析 High Resolution Melt ; high-resolution melting
目的：探讨利用新的高分辨率熔解曲线分析法检测结直肠癌中KRAS基因突变的可行性。
Objective: To evaluate the feasibility and sensitivity of detecting the mutations of KRAS in colorectal carcinoma patients with high resolution melting curve analysis.
结论：新的高分辨率熔解曲线分析法在检测KRAS基因突变时比直接测序法具有耗时短，易操作的优点，并且检测成本低廉，适合在临床开展。
Conclusions: The new high resolution melting curve analysis is more efficient, more convenient than direct sequencing. Moreover, it is a low-cost test, which is suitable for clinic test.
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