该指南首次关注安全性和有效性，以及建议中的出血风险。

For the first time, the guidelines focus on both safety and efficacy and include bleeding risk in the recommendations.

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研究小组在Eating Disorders国际杂志中指出，此研究为首次关注厌食症患者的性别差异。

The study is the first to look at gender differences in anorexia patients, the study team points out in the International Journal of Eating Disorders.

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第二次世界大战期间，钢在低温下的易碎性首次成为人们关注的主要问题。

Steel's fragility at low temperatures first became a major concern during the Second World War.

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