面对这些严重疾病，我们面临着巨大挑战，因此，我们必须想方设法简化业务方法。

Anything we can do to simplify the operational approach is so important because the challenges, like the diseases themselves, are huge.

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面对信息环境的改变，医学图书馆传统的文献检索利用课程面临严重挑战。

In the face of changes in the informational environment, the traditional course of medical library literature retrieval utilization meets huge great challenges.

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瑞安说，他和罗姆尼将“以严肃的方式面对严重的挑战”，但他同时警告说，美国的经济问题是如此之大而没有太多的时间来解决这些问题。

Ryan said he and Mr. Romney will "meet serious challenges in a serious way" but warned the country's economic problems are so big that there is not much time to fix them.

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