第一是儿童生来便带有的基因突变，接着需在儿童阶段有个触发事件，比如导致疾病的感染等。
The first is some kind of genetic mutation that a child is born with followed by a trigger in childhood such as an infection that results in the disease, she added.
KRAS基因突变在恶性肿瘤组织中频发，可预测非小细胞肺癌分子靶向治疗的疗效和预后，针对RAS基因的分子抑制剂研究仍处于初级阶段。
KRAS mutation frequency in tumor tissue, can be predicted non-small cell lung cancer molecular targeted therapy efficacy and prognosis, and molecular inhibitors of RAS genes is still in its infancy.
中国主要河流入海泥沙还具有明显的三个阶段变化特征，即分别在1968年和1984年前后发生了突变。
Periodical analysis showed that abrupt change of sediment load happened in 1968 and 1984, which divided the variation process of river sediment load into three stages.
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