Further study on plasmid stability during high cell density culture revealed vgb expression in A. hydrophila 4AK4 could stabilize plasmid, which would have remarkable significance for large-scale culture.
对培养过程中重组菌质粒稳定性的研究发现，vgb的表达有助于质粒的稳定。
参考来源 - 新型生物材料3·2,447,543篇论文数据，部分数据来源于NoteExpress
发酵过程中维持低葡萄糖水平可以限制细胞的生长速率，提高质粒稳定性和促进青霉素G酰化酶的合成。
Methods:The influence of ammonium sulfate and glucose on plasmid stability and penicillin G acylase activity were conducted in flask shakes and a 5L fermentor.
方法应用肠道细菌毒力和侵袭力检测、宋内菌大质粒DNA图谱分析和猴体口服耐受试验对S7株、S7R株进行安全性和稳定性分析。
Methods Making use of enterobacterial virulence and invasive test, DNA profile analysis and challenge test of rhesus monkey to determine the safety and stability of S7 and S7R.
对重组菌中重组质粒的稳定性进行研究，结果表明该质粒在宿主菌中具有良好的分离稳定性，而结构稳定性较差。
The plasmid stability studies showed that recombinant plasmid has excellent segregational stability but the structural stability was not good in the host cell.
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