衰变加速因子(decay-accelerating factor, DAF)即CD55,表达于所有外周血细胞、内皮细胞和各种粘膜上皮细胞表面,可同C2竞争性地与C4b的结合,从而抑制C4b2b形成并促进其分解。也可促进Bb从已形成的C3bBb中解离。
目的获得纯化并具有生物学活性的人红细胞膜促衰变加速因子。
Objective To purify decay accelerating factor (DAF) with biological activity from human erythrocyte membrane.
衰变加速因子(DAF) 是补体激活途径中的一个重要膜调节蛋白, 转人DAF 基因猪可以作为人器官移植的供体。
Decay accelerating factor(DAF)is one of the important membrane regulating protein in the complement activating ways. The transgenic pigs for human DAF gene can used for xenotransplatations donors.
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