但这种给药方式使血药浓度波动很大，不利于临床的有效治疗。
But the administration makes the plasma concentration change enormously, which is not suitable in treatment.
结论：两种制剂具生物等效性，且缓释片比常释片有峰谷浓度差异小、血药浓度波动幅度小的特点。
CONCLUSION: The two formulations were bioequivalent and the sustained release tablet showed smaller difference between C max and C min and smaller DF compared with the ordinary tablet.
前言：目的：探讨影响丙戊酸钠血药浓度波动的因素，提高丙戊酸钠血药浓度检测的有效性及可利用性。
OBJECTIVE: to observe the factors that influence the fluctuation of serum concentrations of valproic acid and to improve the effectiveness and usefulness of monitoring the serum concentration.
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