获得耐药性（acquired resistance）多由质粒介导，也可由染色体介导，当微生物接触抗菌药以后，通过改变自身的代谢途径，使其能避免被药物抑制或杀灭 细菌耐药分为天然耐药(固有耐药)和获得性耐药.获得性耐药是由于敏感的细菌发生基因突变或获得外源性耐药基因所产生的,如金黄色葡萄球菌获得mecA基因,产生对β内酰胺类抗菌药物的耐药性.
细菌通过各种各样的途径来获得耐药性。
顺铂通常第一次给药时有效，它有一个主要的缺陷：肿瘤获得耐药性，而且重新开始生长。
While cisplatin is often effective when first given, it has a major drawback: Tumors can become resistant to the drug and start growing again.
为了找出原因，研究员分析了那种基因在获得耐药性是转录的最多，辨别几种参与了DNA修复途径。
To figure out why, the researchers analyzed which genes were being transcribed more as resistance developed, and identified several that are involved in DNA repair pathways.
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