以对甲苯乙酮和三氟醋酸乙酯为原料，经缩合、环合两步反应得到2型环氧酶抑制剂赛来昔布，总收率为6 7%。

Celecoxib as a cyclooxygenase-2 inhibitor, was synthesized from p-methylacetophenone and ethyl trifluoroacetate by successively condensation and cyclization in 67% overall yield.

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前言： 以2′，5′-二羟基苯乙酮和原甲酸三乙酯缩合得到6- 羟基- 4- 色酮，再经催化氢化得到标题化合物。

6-Hydroxychroman was prepared by catalytic hydrogenation of 6-hydroxy-4-chromone, which was prepared via condensation of 2′, 5′-dihydroxyacetophenone with triethyl ortho-formate.

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