自杀基因(suicide gene),是指将某些病毒或细菌的基因导入靶细胞中,其表达的酶可催化无毒的药物前体转变为细胞毒物质,从而导致携带该基因的受体细胞被杀死,此类基因称为自杀基因。
效应(by stander effect):第四节基因治疗第四节基因治疗(二)“自杀基因”(suicide gene)疗法(二)“自杀基因”(suicide gene)疗法旁观者效应(by--stander effect):将一定量转染自杀基因的肿瘤细胞和未被转染的肿瘤细...
基于1079个网页-相关网页
...性死亡是由基因控制的细胞主动死亡过程,这些基因可以分为细胞的生存基因(survival gene)和细胞的 自杀基因 ( suicidal gene ),这些基因表达水平决定着细胞的命运,而基因的表达又受到相应的诱导因素和信号传递通路的调控。
基于30个网页-相关网页
其中ced-3 是线虫的 凋亡决定基因,称为“自杀基因(killer gene),若其失活,细胞在整个线虫发 育过程中保持不死;而ced-9 是抑制凋亡的基因。
基于26个网页-相关网页
Objective To investigate the safety and clinical efficacy of Ad-ETK,an oncolytic adenovirus encoding suicide gene (TK gene),to treat patients with solid tumors.
目的 探讨携带自杀基因(TK)的溶瘤腺病毒(Ad-ETK)治疗实体肿瘤患者的安全性及临床疗效。
参考来源 - 溶瘤腺病毒治疗实体瘤安全性及临床疗效的初步评价·2,447,543篇论文数据,部分数据来源于NoteExpress
目的探讨腺病毒介导自杀基因联合前药5FC对人胰腺癌的治疗作用。
Objective To determine the efficacy of adenovirus-mediated suicide gene transduction combined with prodrug 5-fluorocytosine (5FC) as a therapeutic protocol for pancreatic cancer.
目的探索建立受体针对供体抗原特异性T淋巴细胞克隆,转入自杀基因诱导移植耐受的可行性。
Objective to explore the feasibility that the recipient against donor antigen specific t lymphocytes clones are formed, and the suicide genes are induced into the clone.
目的构建携带双自杀基因且可诱导敲除SV40T的逆转录病毒载体,优化目前的肝细胞永生化。
Objective To construct a new retroviral vector with double-suicide genes and knockout-inducible SV40T gene, with the aim of optimizing immortalization of hepatocytes.
Basically, you're introducing this gene into cells that when you give the right inactive drug that will cause the cell to make chemicals that kill it.
概括来说,当你把这个自杀基因导入,含有特定未激活药物的细胞时,二者作用就使细胞生成了,可以杀死自己的化合物
You can see that it would be problem here if the gene that you were trying to give to the cancer cells also went to normal cells-- that would be a problem.
这确实是个问题,如果我们想导入癌细胞的自杀基因,也能进入正常细胞,那问题就大了
This is called a suicide gene.
所以这种基因也叫自杀基因
应用推荐