结论鼻腔给药能够实现药物给药途径上的脑靶向,药物经脂质体包载后能明显增加其脑摄入,提高药效。
CONCLUSION Nasal administration is a better way to target the brain, and the brain uptake of drug modified with lioposomes would be increased, the pharmacodynamics would be improved.
结论:我们制备出了稳定、载药量较大、包封率较高脂质体。
Conclusion: Our prepared liposome shows larger loading capacity and better envelopment and stability.
结果被动载药法制备脂质体包封率较低,主动载药制备脂质体包封率为84.38%。
ResultsThe entrapment efficiency with passive loading method was low, while up to 84.38% with active loading method.
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