次级溶酶体在完成对绝大部分底物的消化分解作用之后,尚有一些不能消化分解的物质残留于其中,成为残留体,有些残留体可以通过细胞的排遗作用,以胞吐的方式被清除,但是有些会沉积在细胞内,常见于脊椎动物和人类的神经元、肝细胞、心肌细胞内的脂褐质。 又称为致密体、老年色素、血褐脂、脂色素、黄色素、透明蜡体及残余小体等。
n. lipofuscin
After 30 days the activity of serum Superoxide dismutase(SOD), Catalase(CAT), Glutatbione peroxidase (GSH-Per) and the content of malondialdehyde(MDA)in brain and Lipofuscin(Lf)in brain and liver, the weight of thymus gland and spleen and the immune-macrophage function were detected.2.
四组小鼠分别喂养30天后,观察小鼠血清中的超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GSH-Per)的活性,测定脑组织中丙二醛(MDA)含量及脑组织和肝脏中的脂褐质(Lf)含量,以及胸腺和脾脏的重量和网状内皮吞噬功能的变化。
参考来源 - 松花粉抗衰老作用的实验研究·2,447,543篇论文数据,部分数据来源于NoteExpress
结论:牛蒡根抗衰老作用的主要作用机制是提高SOD活性,降低MDA、脂褐质含量。
Conclusion: Arctium lappa L. has the remarkable effect of anti-decrepitude, whose main mechanism is to improve the activity of SOD and reduce the content of MDA and lipofuscin.
结果肝细胞内出现大量脂肪滴和巨大线粒体;神经细胞线粒体受损、脂褐质增多;发现凋亡细胞。
Results Triglyceride droplets and giant mitochondrias were observed in hepatic cells, mitochondrias were damaged and lipofuscin increase in neurotic cells, observed apoptosis in both cells.
脑、心脂褐质(LF)的含量和小鼠应激能力:抗疲劳和耐缺氧实验及小鼠腹腔巨噬细胞吞噬功能测定。
The content of lipofuscin(LF) estimated for brain and heart of mice. The stress power was observed. The ability of anti tired and tolerance hypoxia and phago-function of macrophage were estimated.
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