肿瘤的异质化（heterogeneity）：肿瘤的异质化是指由一个克隆来源的肿瘤细胞在生长过程中形成在侵袭能力、生长速度、对激素的反应、对抗癌药物的敏感性等方面有所不同的亚克隆的过程。
目的：探讨用ATP生物荧光肿瘤体外药敏检测技术（ATP-TCA）研究乳腺癌药物敏感性的异质性以及个体化治疗的可行性。
Objective:To investigate the heterogeneity of chemosensitivity in breast cancer using an ATP-tumor chemosensitivity assay (ATP-TCA) and the feasibility of individual chemotherapy.
对每个肿瘤三个不同区域进行免疫组化和银原位杂交，以判定HER2基因扩增的区域异质性和遗传异质性。
Regional and genetic heterogeneity of HER2 gene amplification was determined in three different areas of each tumor by immunohistochemistry and silver in situ hybridization.
理解肿瘤多样化是肿瘤异质性和癌症进化的长期挑战的问题。
Understanding tumor diversity has been a long-lasting and challenging question for researchers in the field of cancer heterogeneity or tumor evolution.
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