However, it is not possible to predict tumor hypoxia in individual patient as there is both inter- and intra- tumoral variation in oxygen status and no consistent relationship between hypoxic fraction and tumor size or phase.
但由于肿瘤内外氧水平存在差异，而且乏氧程度与肿瘤大小没有确定联系，所以不可能预测单个病人的肿瘤乏氧程度。
参考来源 - 新型肿瘤乏氧显像剂的设计、合成及活性研究·2,447,543篇论文数据，部分数据来源于NoteExpress
厌氧菌能在肿瘤乏氧及坏死区选择性定植，引起溶瘤效应；
Anaerobic bacteria can selectively colonize and cause oncolysis in hypoxic and necrotic areas of solid tumors.
生物还原剂是一种具有肿瘤乏氧靶向性的前药，它会在还原性环境中被还原产生具有细胞毒性的代谢物。
Bio-reductive drugs are pro-drugs that can selectively target the hypoxia cells in tumors. In reductive environment, they are reductively metabolized to generate toxic species.
结论肿瘤乏氧与VEGF表达关系密切，乏氧可诱导VEGF表达的增高，而VEGF表达能促进肿瘤血管生成。
Conclusion tumor hypoxia had a close relationship with the expression of VEGF, and VEGF could promote tumor angiogenesis.
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