而大观霉素和林可霉素耐药性较高，其耐药率分别为75.4％和50.8％。

Spectinomycine and Lincomycin are high drug resistance, the resistance rates were 75.4% and 50.8%.

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经过240周的治疗后，HBV聚合酶的蓄聚率、病毒的耐药率和临床耐药率分别是29%，20%和11%。

After 240 weeks of therapy, the cumulative rates of HBV polymerase mutations, virologic resistance, and clinical resistance were 29%, 20%, and 11%, respectively.

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耐药性最强的是灰黄霉素，耐药率达86.6%，其次为氟康唑、伊曲康唑，耐药率分别是19.2%、10.6%。

The strongest drug resistance was griseofulvin, which reached up to 86.6%, followed by fluconazole (19.2%) and itraconazole (10.6 %).

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