考虑到这些限制，本次的预算似乎不可能深得人心了。
Given these constraints, the budget was never going to be pretty.
考虑到人类是这些生态系统的一部分，你可能听说过，水资源短缺可能会限制你可以使用多少水，特别是近些年夏天的时候，
Consider humans as part of these ecosystems, you've probably heard about water shortages or restrictions on how much water you can use, especially in the summer time, in recent years.
但他们说，尽管有这些限制，病人和供者应考虑到用罗格列酮治疗中潜在的严重不良的心脏治疗。
But they say that despite these limitations, patients and providers should consider the potential for serious adverse cardiac effects of treatment with rosiglitazone.
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