血管收缩物质 vasoconstrictor substance
Endothelin-1(ET-1)is the most strong and lasting perfuse vaso-excitor material which known at present. And it takes important role in the adjusting and controls process of regional flow filling.
内皮素-1(endothelin-1, ET-1)是目前已知的作用最强和最持久的缩血管物质,对局部血流灌注调控具有重要作用。
参考来源 - 新生儿缺氧缺血性脑病患儿血液中VEGF和ET·2,447,543篇论文数据，部分数据来源于NoteExpress
血管内皮细胞分泌的强缩血管物质。
Vascular endothelial cell excretes , strong vasoconstrictor.
结论：高血压时血管细胞为抵消或减轻et - 1等缩血管物质的过度分泌而代偿性的合成和分泌adm增多。
Conclusion: During the course of hypertension, vascular cell synthesize and secrete more ADM to compensate for the excessive secretion of et 1.
提示MT可以通过抑制ET的释放和拮抗ET的缩血管效应，发挥其内源性抗损伤物质的作用。
Tihe resulis suggest that MT could exert its injury-resistant action, as an endogenous defensive substance through inhibition of ET release and anlagonization against ET-induced vasocontraction.
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