最显著的神经病理改变是新纹状体中度多刺的神经元的优先丢失。
The most significant neuropathological change is a preferential loss of medium spiny neurons in the neostriatum.
结论移植的神经干细胞能在PD模型小鼠纹状体存活,并可分化出特定的多巴胺能神经元。
ConclusionsThe transplanted multipotent NSCs could survive, differentiate into functional dopamine neurons in the brains of PD model mice.
目的:研究古拉定、川芎嗪、丹参对6-羟基多巴胺(OHDA)处理后大鼠的黑质多巴胺(DA)神经元及纹状体细胞外液DA的影响。
Objective:To study the effect of glutathione (GSH), Ligustrazine and Salvia miltiorrhiza on dopamine (DA) and its metabolites of corpus striatum and DA neurons in rats injected with 6-OHDA.
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