结果:AL L P16基因高度甲基化或纯合缺失发生率为80 % ,而对照组无一例P16基因失活;
Results:In ALL, the incidence of P16 hypermethylation or homozygous deletion is 80%, there is no abnormal in control.
第8外显子纯合性缺失率为29.3%(12/41),且与患者TNM分期、病理分级及淋巴结转移有关(P<0.05);
The rate of homozygous deletion of Exon8 was 29.3%(12/41), and it was related to the tumor pathological grade, TNM stage and lymph node metastasis (P<0.05).
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