它们结合到目标基因上并降低它们的作用。

They bind to target genes and decrease their function.

youdao

这种结合活性使得miRNA得以定向沉默目标基因。

This binding activity allows microRNAs to silence the expression of select genes in a targeted manner.

youdao

目标基因替换是基因功能分析的重要手段。

Targeted gene replacement (TGR) is an important technique for gene function analysis.

youdao

Take a plasmid, cut it open, insert a gene that we want into the plasmid, and then put that plasmid in a host cell, and let the host replicate it.

取一个质粒,把它切开,把目标基因放进去,然后把这个质粒植入到宿主细胞,让宿主来进行复制

耶鲁公开课 - 生物医学工程探索课程节选

It's only going to bind to fragments that contain that piece of the gene, and it will make those visible to you in some way so you can see where your gene traveled.

它只会和有那段序列的片段结合,从而能让你看到那段片段在哪里,你就可以知道目标基因片段到了哪个位置

耶鲁公开课 - 生物医学工程探索课程节选

Before we talk about how to do it-- and we don't have perfect ways to do it yet but I'll describe some of the ways that are used, I want to talk just briefly on this slide about what the goals for gene therapy might be.

在讲具体怎么做之前--,现在还没有任何一种方法是完美的,但我还是要讲讲一些已经应用的方法,我借助这张幻灯片简要介绍一下,基因治疗的可能目标

耶鲁公开课 - 生物医学工程探索课程节选