痘苗病毒(vaccinia virus)属痘病毒(Poxvirus)。在血清学和免疫学上与天花病毒及牛痘病毒有密切关系,被用作天花预防疫苗的抗原。
重组痘苗病毒载体在消化道肿瘤基因治疗中的应用 热点之一。基因转移是基因治疗的关健和基础,寻找高效、安全的载体表达系统是基因治疗研究中的重点和难点。痘苗病毒(vaccinia virus,VV)作为基因治疗的载体系统之一正越来越受到人们重视[1],已成为继逆转录病毒和腺病毒之后作为基因治疗载体
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重组痘苗病毒 Recombinant vaccinia virus ; VaCcinia virus ; VV
痘苗病毒血凝素 VVHA
甘油痘苗病毒 [病毒] glycerinated vaccine virus
改良型痘苗病毒天坛株 MVTT
牛痘苗病毒 vaccinia virus ; VV
痘苗病毒生长因子 VVGF ; vaccinia virus growth factor
是继痘苗病毒 Vaccina virus ; VV
痘苗病毒的血凝素基因 Hemagglutinin
An enhancer-like element VV16 from Vaccinia virus genome DNA was obtained by using the plasmid with CAT reporter gene.
利用带有氯霉素乙酰转移酶报道基因的检测载体,从痘苗病毒基因组DNA中筛选到一个增强子样片段VV16。
参考来源 - 痘苗病毒VV16原核增强子样序列的克隆及其结构与功能的研究 Functional and Structural Study of the Prokaryotic Enhancer·2,447,543篇论文数据,部分数据来源于NoteExpress
研究人员们首先将痘苗病毒中在正常细胞中生长所必须的两个基因去除。
The researchers began by removing two genes from a vaccinia virus that are necessary for its growth in normal cells.
所建立的痘苗病毒系列检测方法,为天花相关病毒的实验室诊断奠定了基础。
The detection methods for vaccinia virus were developed and provide a base for laboratory diagnosis of variola-related viruses.
结果显示,MVA同源重组频率虽然比其他痘苗病毒株要低,但仍然是较高的。
The results showed that the recombination frequency of these rMVAs was significantly high, though lower than that observed in other vaccinia virus strains.
Remember that the lucky thing about the smallpox vaccine was that a naturally occurring attenuated form of the smallpox virus variola called vaccinea was found.
对于天花病毒来说,幸运的是,存在一种自然发生的,被称作痘苗病毒的,天花病毒的衰减疫苗
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