科克伦系统评价数据库于2007年收录的一份研究报告显示，研究人员曾集中分析了六例临床实验病例，以观察咖啡因对哮喘的疗效。
In a 2007 study in the Cochrane Database of Systematic Reviews, researchers pooled and analyzed the results of a half dozen clinical trials looking at the effects of caffeine on asthmatics.
报告真实资料的个案报告、病例分析、调查和其他观察性研究均包括在内，然而评论文章、译文和临床试验均未包括在内。
Case reports, case series, surveys and other observational studies were included if they reported factual data, but review articles, translations and clinical trials were excluded.
大样本病例观察少，合作规范临床研究不够；
Observation on big sample cases lacked and cooperated standard clinical research was deficient.
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