设计：随机对照病例观察。

DESIGN: Randomized controlled case observation.

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使用病例观察表以了解患者疾病相关情况。

Use cases observed in patients with disease-related tables in order to understand the situation.

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大样本病例观察少，合作规范临床研究不够；

Observation on big sample cases lacked and cooperated standard clinical research was deficient.

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