在美国这种细菌每年造成的死亡比艾滋病还要多，部分是由于它能很快对抗生素产生耐药性。

The bacterium is responsible for more U.S. deaths each year than HIV/AIDS, in part because it quickly develops resistance to antibiotics.

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但由于水溶性差、易产生多药耐药性和毒性较强等缺点限制了它们在临床上的应用。

However, their therapeutic use is often hindered by problems such us poor water solubility, acquired drug-resistance and strong toxicity.

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