本发明涉及重组多肽,特别是结合纤连蛋白的Ed-B-同种型并可阻断其功 能的抗体或抗体片段。
The invention relates to recombinant polypeptides, in particular antibodies or antibody fragments, which are able to bind the ED-B isoform of fibronectin and block the function thereof.
本发明也揭示包含所述抗rage抗体及其RAGE结合抗体片段的医药组合物及其用于治疗RAGE相关疾病的用途。
Also disclosed are pharmaceutical compositions comprising such anti-RAGE antibodies and RAGE-binding antibody fragments thereof, and their use for treatment of RAGE related diseases.
竞争抑制实验表明所获人源抗体片段与亲本鼠源单抗结合同一抗原表位。
Binding competition studies demonstrated that they bound the same epitope of the Ag as the parental Ab.
The IgM is really five IgG-type molecules that are linked together through disulfide bonds, such that their FC portions are all pointing in and their antibody binding portions are all pointing out.
gM是由五个IgG分子组成的,IgG分子之间通过二硫键连接,免疫球蛋白尾部的FC片段都指向内侧,而抗体的抗原结合位点都指向外侧
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