热休克因子1 (HSF1)是一种转录因子，在正常时不活化，应激时活化而具有反式激活能力。
As a transcription factor, heat shock transcription factor 1 (HSF1) is activated during stress and subsequently trans-activate its downstream factors.
该文简要综述热休克因子在抗炎反应、肿瘤发生与维持、生长发育、衰老等生理病理过程中的重要生理功能。
This article summarized the physiological functions of HSFs in anti-inflammatory response, tumorigenesis and maintenance, growth, aging and other physiological or pathological processes.
但目前尚未阐明热对成骨细胞与破骨细胞偶联关系的影响及热休克蛋白70（HSP70）和热休克因子2（HSF2）对成骨细胞RANKL的调节机制。
The influence of the heat for the relationship of osteoblast and osteoclast and the regulatory mechanism of HSP70 and HSF2 for the RANKL of osteoblast has been not interpreted thoroughly.
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