通常，混血狼是指某一灰狼亚种（除家犬）与家犬的杂交后代。其实混血狼是指各大洲不同的灰狼亚种之间的杂交的后代，包括某个灰狼亚种（除家犬）与家犬的混血后代（通常所说的狼和狗的后代）。混血狼并非家犬或是野狼，而是亚种之间的杂交物种，所以把混血狼称为狗或狼犬是错误说法，非常不严谨。在家犬系列的混血后代完全成熟后，他们大多会具备与野狼一样的外形特征和生活习性。
根据DNA和颅骨形状可以证明，这种混居生活已经繁育出了具有生存能力的杂交后代，而且，混血狼已经扩散到中大西洋沿岸各州，诸如纽约和宾夕法尼亚。
The pairings created viable hybrid offspring—identified by their DNA and skulls—that have been found in mid-Atlantic states such as New York and Pennsylvania.
在一些州中，混血儿被归类为野生动物，而且拥有者要持有相同类型的许可证而且做为一只狼关进笼内。
In some states, hybrids are classified as wild animals and owners are required to possess the same type of permits and caging as for a Wolf.
繁殖狼混血儿的许多繁育家促进拥有'狼血统'的幼体而且甚至依照“狼血统所占的比例的多少”来制定他们价格。
Many breeders who deal in Wolf hybrids promote the 'Wolf content' of the pups and even set their prices according to the 'amount of Wolf blood' in the litter.
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