备注：在意向治疗者人群中的初步分析中采用混合模型重复测量（MMRM）方法。显著性检验基于每个治疗组从治疗开始到治疗结束的最小二乘均值改变，采用双侧检验，临界值为0.05.
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前言：目的：探讨混合线性模型在临床试验重复测量资料分析中的应用。
Objective: To explore the application of the mixed linear model in the repeated measures data of clinical trials.
方法：利用混合线性模型分析结果指标为定量资料的重复测量资料，通过参数和标准误的估计得出统计学结论。
Methods: the repeated measure data were analyzed with quantitative data by mixed linear Model and conclusions were drawn according to the parameter and standard error.
方法：用混合效应线性模型和单因素方差分析处理重复测量资料并比较。
Method: Make use of mixed effects linear model and single effect analysis of variance to deal with the repeated measure data.
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