自然界中有一类名为转录因子的蛋白可调节(升高或者降低)基因的活性，该技术正是基于该机理。
The technique relies on a natural process by which the activity of genes is raised or lowered by proteins called transcription factors.
作为端粒酶活性的关键决定因子，端粒酶逆转录酶的调控研究已取得了重大进展，但具体机制仍不清楚。
As a critical factor of telomerase activity, much progression has been achieved in the study of regulation of human telomerase reverse transcriptase, but the detail mechanism is still not clear.
具体地，本发明显 示E2-EPF5活性的抑制降低VEGF以及其他在低氧应答中由转录因子 HIF-1调节的蛋白质的产生。
In particular, inhibition of E2-EPF5 activity is shown to reduce the production VEGF, as well as other proteins regulated the transcription factor HIF-1, in response to hypoxia.
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