他一天吃三次药，没什么效果。

He took medicine 3 times a day, which didn't work.

youdao

一种设计效果很好，反复应用于其他地方，加上一些看似没什么影响的改进，突然有一天它就不奏效了。

Perhaps a design works so well. It is adopted elsewhere again and again, with seemingly harmless improvements, until, suddenly, it does not work at all anymore.

youdao

他已经尝遍了各种心理的和药物的疗法，但似乎没什么效果。

He has tried numerous types of psychotherapy and medication but nothing seemed to help for long.

youdao

You could tell your friend that you've tried it and it didn't work by using the "I've already" pattern.

你可以用“I've already”句型告诉你朋友，你已经用过了，却没什么效果。

I've already 课堂 - SpeakingMax英语口语达人