来氟米特的药物标签中有黑框警告：孕妇和准备要小孩的妇女禁用。
The drug label already features a boxed warning stating that leflunomide is contraindicated for pregnant women and for women of childbearing potential not using reliable contraception.
结论：生地马钱丸配合来氟米特治疗RA疗效优于单用来氟米特，且安全性好。
Conclusion: Habitat Strychnos pill with leflunomide for the treatment of RA is more effective than leflunomide alone, and the safety is good.
来氟米特通过随机双盲安慰剂对照试验研究表明，对强直性脊柱炎急性期没有效果。
Leflunomide was evaluated in a randomized, double-blind, placebo-controlled study in active ankylosing spondylitis but was not found to be effective.
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