重要的是要注意，不过，在不同的肌营养不良基因突变可能需要不同的寡核苷酸药物。
It is important to note, however, that different mutations in the dystrophin gene could require different oligonucleotide drugs.
由于核苷酸切除修复、药物转运和药物代谢通路在铂金药物功能中的重要性，这篇综述重点总结了这些通路中的基因表达和非癌细胞DNA变异与铂金疗效的关系。
We focused on several key pathways, including nucleotide excision repair, drug transport and metabolism. Both expression and germline DNA variation were evaluated in these key pathways.
经修饰寡核苷酸克服了与当前反义药物有关的许多问题。
The modified oligonucleotides overcome many problems associated with current antisense drugs.
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