High mobility group protein box 1 (HMGB1), a protein previously known as a nonhistone chromosomal protein, has been implicated in cellular functions, including maintenance of nucleosomal structure and stability, and binding of transcription factors to their cognate DNA sequences.
既往,高迁移率族蛋白B1被认为是典型的非组蛋白,参与核小体结构的构建及稳定,并参与基因转录及DNA重组、修复和复制。
参考来源 - 高迁移率族蛋白B1的生物学效应及在几种疾病发病中的作用·2,447,543篇论文数据，部分数据来源于NoteExpress
利用这种新型工具，Luger和他的同事进行了X射线晶体学和生物物理学研究，来看甲基化怎样影响染色质和核小体结构。
With this new set of tools, Luger and her colleagues did X-ray crystallographic and biophysical studies to see how methylation affects the structure of chromatin and nucleosomes.
一种组蛋白的八聚物把DNA打包成一种叫做核小体的结构。
An octa-mer of histones package DNA into a structure called a nucleosome.
研究人员怀着了解两种不同的甲基化标记怎样影响核小体和染色质结构的目的开始工作。
The researchers began their work with the goal of learning how two different methylation marks affect the overall structure of nucleosomes and chromatin.
应用推荐