人胚胎干细胞(hEScell)优化培养的进展-方法技术-生物探索 关键词：人胚胎干细胞；未分化状态；培养体系 [gap=1866]Key words: human embryonic stem cell; undifferentiated state; culture system
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[0010] (a)其固有地处于未分化状态(innately undifferentiated)；[0011] (b)其以大量液泡（vacuole)为形态学特征。' o: p; t% D* R0 U: z' n3 ?
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天然未分化状态 innately undifferentiated
这就引出问题，转录因子是否能直接诱导其它明确的体细胞，而不仅是未分化状态的细胞。
This raised the question of whether transcription factors could directly induce other defined somatic cell fates, and not only an undifferentiated state.
一些通常在发育胚胎中活跃的基因会被分化细胞(比如皮肤细胞)表达，促使细胞回复到未分化状态。
A handful of genes that are normally active in the developing embryo are expressed in a differentiated cell, such as a skin cell, causing that cell to revert back to its undifferentiated state.
胚胎干细胞(ES细胞)具有自我更新、无限增殖、保持未分化状态和向所有三个胚层分化的潜能。
Embryonic stem cells (ES cells) are unique cell populations with the ability of self-renewal, unlimited proliferation, multipotent differentiation and maintaining their undifferentiated state.
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