忧郁发作的时候，又会情绪低落、无助无望，甚至觉得活著没有价值和意义，甚或自杀。
During the Major Depressive Episode, patients feel so depressed, helpless, and hopeless that they consider life is worthless or meaningless. These feelings may even lead to suicide.
这让他看起来不是天真、过度值得信赖，就是脆弱、无望的无助。
This makes him appear either naive and too trusting, or vulnerable and hopelessly helpless.
如果你感到抑郁，你可能感到筋疲力尽、无助、无望。
If you have depression, you may feel exhausted, helpless, and hopeless.
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