研究背景及目的动脉粥样硬化斑块破裂(Plaque Rupture)是引发心肌梗死、脑血栓等心脑血管急性事件的主要原因。而动脉粥样硬化斑块内炎症细胞的浸润及继发的炎症反应是引发动脉粥样硬化...
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冠状动脉斑块破裂 coronary plaque rapture
However, it is unclear that what is the link or key factors for triggering the plaque rupture.
但触发斑块破裂的始动因素或关键环节目前尚不清楚。
参考来源 - CD40Pathological studies show that the vulnerable p1aque are rich inmonocyte-derived macrophages, which tum into foam cells and contribute to lipid-ladenplaque; release proteolytic enzymes that degrade extracellular matrix and weaken a thinoverlying flbrous caPs, precipitating plaque disruPtion.
病理学研究表明粥样斑块易破裂区常有大量单核细胞源巨噬细胞浸润，通过泡沫细胞化形成富含脂质的易损斑块；分泌蛋白溶解酶降解细胞外基质削弱纤维帽而促使斑块破裂。
参考来源 - CD36和过氧化物酶体增殖因子活化受体γ在不稳定斑块形成中作用的研究·2,447,543篇论文数据，部分数据来源于NoteExpress
能在不稳定冠脉斑块破裂前识别它吗？
Can We Identify Unstable Coronary Plaques Before They Rupture?
其斑块破裂背后的分子和细胞特征已经被广泛的研究。
Underlyingcellular and molecular characteristics of plaque rupture have been studied extensively.
而且，运动可能会增加斑块破裂的风险，引发心肌梗死。
The act of exercising, however, may increase the risk that the plaques will rupture, precipitating a heart attack.
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