磺化三苯基季膦盐的合成及其抗肿瘤活性_医网打尽文献搜索 关键词 季膦盐;合成;抗癌活性 [gap=546]Key words phosphonium;synthesis;antitumor activity
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技术文摘 关键词:大豆多肽,抗癌活性,凝胶过滤,相对分子量 [gap=1033]Key words:soybean peptides;anti-cancer activity;gel filtration;relative molecular weight
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Objective To develop a new generation of anticancer drugs of paclitaxel,the quantitative structure-anticancer activity(PIDact) relationship(QSAR) of paclitaxel analogues was studied.
目的为了寻找新一代紫杉醇类抗癌药物,研究紫杉醇类似物分子结构和抗癌活性(PIDact)之间的定量构效关系。
参考来源 - 紫杉醇类似物抗癌活性与分子结构的定量构效关系Among synthesized compounds, 3c, 3e and 3f showed potential antitumor activity with the IC50 of 3.8, 2.0,1.3 and 2.5, 2.5, 1.1 μmol/L against SMMC-7721 and Bel-7402 cells, respectively.
结果表明,所合成的7个新化合物中,化合物3c、3e、3f对上述2种细胞株均表现出显著的体外抗癌活性,其IC50(μmol/L)值分别为3.8、2.0、1.3和2.5、2.5、1.1。
参考来源 - 3SY-801, a new hepatoprotectant developed by our institute, has been shown to have hepatoprotective action and anti-cancer activity with low toxicicity.
SY-801为我所研制的一种抗肝炎新药,具有明显的保肝作用及抗癌活性,且毒性甚低。
参考来源 - 抗肝炎新药SYThe results showed that compounds 2a and 4 had better anti-tumor activity and lower toxicity.
结果显示:化合物2b和4有较好的抗癌活性和较低的毒性,为较优的抗癌先导物。
参考来源 - 白藜芦醇类似物的合成及其生物学性质研究The bioactivity of complex (1) was preliminary studied and the antibacterial antitumor activity tests show that it exhibits a good bioactivity.
生物活性测试表明,配合物(1)具有较好的抑菌作用及抗癌活性。
参考来源 - 新型有机锡(Ⅳ)羧酸酯的合成、表征及晶体结构的研究Daunorubicin (DNR) is one of the most important anthracyclines, whose anticancer activity is linked with DNA and inhibition of both DNA and RNA synthesis.
柔红霉素是一种重要的蒽环类抗肿瘤抗生素,能与DNA结合,抑制核酸合成,表现出抗癌活性。
参考来源 - 心肌肌球蛋白的提纯及与柔红霉素作用的荧光研究Relationship between structure and activities was studied by investigation of anticancer activities of substituted porphyrins toward malignant tissues such as liver cancer cells.
实验结果表明所有卟啉化合物杀伤癌细胞的活性都不同,其中以四取代氮芥卟啉效果最好。 通过研究卟啉化合物对肝癌细胞的抗癌活性,探讨了其结构与抗癌活性的关系。
参考来源 - 氮芥和哌嗪衍生物卟啉的合成、表征及生物活性研究·2,447,543篇论文数据,部分数据来源于NoteExpress
木鳖子、大黄和甘草均含有抗癌活性成分。
The cochinchina momordicae seed, rhubarb, liquorice root all contain anti-cancer activity components.
喜树碱及其衍生物是一类具有抗癌活性的生物碱。
Camptothecin and its derivatives are alkaloids possessing anti tumor activities.
结论:大蒜油能激活枯否细胞,从而增强其抗癌活性。
Conclusion: Garlic oil can activate Kupffer cell and enhance its anticancer activity.
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