对核苷类化合物糖环部分的化学改造一直是发现新的具有抗病毒、抗肿瘤或其他生物活性的核苷类先导化合物的重要途径之一。
The chemical modification of sugar moiety in nucleoside or nucleotide is always an important way to discover new lead compounds with anti-viral, anti-tumor and other biological activities.
克来夫定为嘧啶类似物，对HBV具有持续有效的抗病毒活性。
Clevudine is a pyrimidine analogue with potent and sustained antiviral activity against HBV.
结果表明：提取物的抗病毒活性因提取溶剂和提取方法的不同而异。
The results showed that antiviral substance activity is dissimilar based on extracts from walnut peel with different solvent and methods.
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