基因内部不同位置上的碱基发生了两次突变，其中一次抑制另一次突变的遗传效应，后一基因称为前一基因的抑制基因。
病理学：p53肿瘤抑制基因突变，第11p15基因座杂和性丢失。
Pathology: p53 tumor suppressor gene mutation, loss of heterozygosity (LOH) at 11p15 locus. PAX-FKHR gene fusion.
氧化应激可以导致DNA链断裂、DNA位点突变、DNA双链畸变和原癌基因与肿瘤抑制基因突变等形式的DNA损伤；
Oxidative stress can cause DNA damage, such as DNA strand breaks, point mutations, aberrant DNA cross-linking, and mutations in proto-oncogenes and tumor suppressor genes;
该药物能够准确的将正确的染色体数目导入每一新细胞，产生非整倍体细胞，能够用于治疗由于肿瘤抑制基因突变导致的肿瘤。
Drugs that inhibit accurate delivery of the right number of chromosomes to each new cell, resulting in aneuploidy, would be used to destroy tumors caused by mutations in the tumor suppressors.
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