Fix Central帮助系统保持最新状态，并且是手动检索升级数据的最佳方法。

Fix Central helps you keep your systems up to date and is the best method of manually retrieving data for your upgrades.

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并手动检索其主要研究结果、综述、临床指南，以及与之相关的引文中所出现的参考文献。

Hand searches also were conducted of the reference lists of primary studies, review articles, and clinical guidelines along with full-text review of any citation that appeared relevant.

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