虽然许多原癌基因和肿瘤抑制基因被广泛表达，这些基因的突变与特定的器官或细胞类型的癌有关。
Although many proto-oncogenes and tumor suppressor genes are widely expressed, the mutation of these genes is associated with cancer of specific organs or cell types.
热休克蛋白可能有助于细胞周期调控通过与原癌基因的产品或抑癌基因的产品。
Heat Shock Proteins may contribute to cell cycle regulation by interacting with proto-oncogene products or tumor suppressor gene products.
一般情况下，它们都处于封存不动状态，但在特殊情况下，原癌基因被激活或抗癌基因丢失，人就会患上癌症。
Under normal circumstances, they are sealed in a fixed state, but in exceptional circumstances, the proto-oncogenes or tumor suppressor genes are activated is lost, people will suffer from cancer.
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