我最大的问题在于发音不正确。

My biggest problem is that I can't get the pronunciation right.

youdao

很难记住人的名字是我最大的问题。

Remembering people's names is my biggest problem.

youdao

我最大的问题就是我太忙了。

My biggest problem is that I'm too busy.

youdao

But I see our biggest threats are the implosion of the whole Middle East, to start with.

我认为我们面临的最大威胁,首先是中东问题。

普林斯顿公开课 - 国际座谈会课程节选

I would say that the king of New York right now is real estate as opposed to Wall Street

我觉得纽约现在最大的问题就是房地产行业而不是华尔街，

纽约的负面变化 - SpeakingMax英语口语达人

I just think that that's the whole moral issue is that there was no consulting of the cabin boy and that's what makes it the most horrible is that he had no idea what was even going on.

我只是觉得，最大的道德问题,就是根本没人征得过派克的意见,最可怕的是,他当时是完全被蒙在鼓里的。

耶鲁公开课 - 公正课程节选