目前螺旋霉素生物合成的发酵杂质含量过高，导致成品收率过低，杂质含量不符合药典规定。

There are several impurities in the spiramycin fermentation broth which leads to a lower yield and lower quality of the product.

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第三，改进产品的收率管理，补充测试程序筛选能力的不足，保证成品质量。

Third, improve the yield management and it's for making up the insufficiency of the testability of test program to guarantee the quality of the finished products.

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结果伏立康唑的总收率为25.3%，远远高于文献报道的收率（4%），制得的伏立康唑经过重结晶得到色谱纯度>99%的成品。

Results The total yield was 25.3%, far more than 4%, which was reported in the literature. After recrystallization, the purity of the finished product was higher than 99%.

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