这些具有深远的效果，正如对于慢性病治疗患者可能需要更高剂量的止疼片。

This has far-reaching effects, as in the treatment of chronic pain sufferers may need higher dosages of painkillers.

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目的：研究小剂量口服罗盖全治疗慢性肾衰竭（CRF）继发性甲旁亢（SHPT）早期患者的疗效和副作用。

Objective:To study the curative effect and side-effect of low doses of oral calcitriol on early secondary hyperparathyroidism(SHPT) associated with chronic renal failure(CRF).

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例如，肾衰或慢性肾病的患者，我们需要非常小心的逐步减少药物剂量。

For example, in patients with renal failure or chronic renal disease, we need to be very careful to reduce the dose of the drug by titration.

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