尽管如此遭遇，他从未丧失活下去的意志。

In spite of what happened, he never lost the will to live.

《牛津词典》

据说他已经丧失了活下去的意志。

He was said to have lost his will to live.

《柯林斯英汉双解大词典》

意志消沉导致思维混乱、丧失判断力，还可能使你无法从事简单的日常活动。

Depression causes disordered thinking and judgment, and can keep you from functioning and doing simple everyday things.

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