恶性胶质瘤，源自神经上皮的肿瘤统称为胶质瘤（胶质细胞瘤），占颅脑肿瘤的40-50%，是最常见的颅内恶性肿瘤。根据病理又可分为星形细胞瘤、髓母细胞瘤、多形胶母细胞瘤、室管膜瘤、少枝胶母细胞瘤等。
n. spongioblastoma ; glioblastoma
misc. spongiocytoma
At present, there is no effective treatment for patients with malignant and recurrent glioma. Patients with malignant glioma have a very poor prognosis, even with treatment including surgical resection, radiation, chemotherapy.
目前,对于恶性和复发的胶质瘤患者仍没有有效的治疗手段,虽然采取手术切除、放疗和化疗的治疗方法,但是恶性胶质瘤患者的预后并不乐观,基因治疗被认为是一种很有前景的胶质瘤治疗方法。
参考来源 - β干扰素基因治疗人脑胶质瘤的实验研究TJ8510 cell line (human brain glioblastoma cell line) was provided by the Neurological Research Institute of Tianjin Medical University Affiliated Hospital. The experimental animals were 36 BALB/C nude mice congenitally having no thymus.
TJ8510细胞(人脑恶性胶质瘤细胞系细胞):天津医科大学总医院神经病学研究所提供;实验动物:先天性无胸腺BALB/C裸鼠36只。
参考来源 - 肿瘤坏死因子α基因转导的肿瘤浸润淋巴细胞体外生物学活性及不同转输方式的比较(英文)·2,447,543篇论文数据，部分数据来源于NoteExpress
而大多数现有的针对恶性胶质瘤的临床治疗方式只作用于一条通路。
Most standard clinical treatments for glioblastoma currently target just one pathway.
恶性胶质瘤是脑癌中最致命的类型，目前对此尚无有效的治疗方法。
Malignant glioma is among the deadliest types of brain cancer for which there currently is no effective treatment.
恶性胶质瘤是侵袭程度最高的脑瘤之一，病人存活时间基本不超过两年。
Glioblastoma is one of the most aggressive brain tumors, killing nearly every patient within two years.
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