这些公司据信对经济有重大影响力。

These firms are regarded as the engine room of the economy.

《柯林斯英汉双解大词典》

最重要的是，科学家们开始意识到气候变化对人类物种的进化有重大的负面影响。

Most important, scientists are beginning to realize that the climatic changes have bad a major impact on the evolution of the human species.

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运行时环境的配置对运行中的应用程序的可伸缩性和可靠性有重大影响。

The configuration of the run-time environment has a significant impact on the scalability and reliability of the running applications.

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