方法：羟脯氨酸法、间接酶联免疫吸附法（ELISA）测定博莱霉素A6（BLMA6）诱发的小鼠、大鼠肺纤维化模型肺组织胶原含量及合成，阿利新蓝法测定其糖胺多糖（GAG）含量；
METHODS: Hydroproline determination and ELISA were used for measuring the content of collagen, Alcian blue assay for BLM-A6 induced glycosaminoglycan (GAG) in the lung tissues (rats, mice).
结果大鼠实验性肺纤维化模型成功；
Results: The rat model of pulmonary fibrosis was established.
方法采用大鼠油酸尾静脉注射制作急性肺损伤后肺纤维化模型，观察红霉素对损伤肺组织中中性粒细胞聚集及氧自由基的干预作用。
Methods: Model of fibrosis of lung with injection by oil-acid to rat, observed the effect of erythromycin to neutrophil and oxygen-free radical.
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