方法对36例股骨头缺血性坏死病人采用留置导管连续灌注治疗，将高浓度大剂量的药物直接作用于局部。
Methods 36 patients with avascular necrosis of femoral head used cannulation and continuous medicine injection with high density and medicine was at high concentration in injury place.
目的：通过血药浓度监测，提高对小儿急性淋巴细胞白血病大剂量甲氨蝶呤化疗的有效性和安全性。
OBJECTIVE: to improve the efficacy and safety of high dose methotrexate (HDMTX) chemotherapy in the treatment of children with acute lymphoblastic leukemia through blood concentration monitoring.
排泄延迟更易出现于使用高剂量药物时。在血药浓度监测下使用大剂量MTX安全可行。
Application of high-dose MTX therapy under the monitoring of blood MTX concentration is safe and feasible.
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